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Darunavir, often marketed under the name Prezista by Janssen, is a key medication used in the treatment of HIV, typically as part of a combination therapy with ritonavir or cobicistat to enhance its effectiveness. Available in 600 mg and 800 mg doses, it is prescribed for both treatment-naïve and experienced patients. This protease inhibitor works by preventing the virus from maturing and replicating, significantly improving viral suppression when paired with other antiretroviral agents like abacavir and lamivudine. While effective, common side effects of darunavir and ritonavir can include nausea, headache, and occasional liver enzyme elevation. The cost of Prezista or its generic equivalent, such as Daruvir, varies, but financial assistance programs may help offset expenses. As part of a comprehensive regimen, it remains an essential tool in HIV management, often paired with Genvoya or other therapies for tailored patient care.
